Serotonin antagonist antiemetics: Progress and concerns
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چکیده
منابع مشابه
The cardiotoxic potential of the 5-HT(3) receptor antagonist antiemetics: is there cause for concern?
PURPOSE To review and evaluate the potential cardiac effects of 5-HT(3) antiemetic treatment in patients who may be predisposed to cardiac complications resulting from malignancy, cytotoxic oncologic regimens, or preexisting comorbid conditions. DESIGN A literature review was conducted on the negative cardiovascular effects of chemotherapeutic agents, and, more specifically, on the cardiac in...
متن کاملAntiemetics: a Review
The act of emesis is controlled by the vomiting centre in the medulla, which integrates afferent input from the vestibular system, the chemoreceptor trigger zone (CTZ), the cortex and the gut. Nausea and vomiting induced by several cancer chemotherapy agents is often the most distressing side effect of treatment. The mechanism of action of antiemetic is related to blockage of various type of re...
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Curcumin exhibits both cancer- preventive activity and growth inhibitory effects on several neoplastic cells including human colon cancer. Serotonin and its receptors have also been implicated in tumor development. This study investigated the effect of ritanserin, a selective serotonin 5HT2A receptor antagonist, alone and in combination with curcumin on colorectal cancer cell lines. Result...
متن کاملAntiemetics in cancer chemotherapy.
Nausea and vomiting induced by several cancer chemotherapy agents is often the most distressing side effect of treatment. The mechanisms are quite complex. The vomiting center in the reticular formation can be stimulated by either afferent stimuli from the gastrointestinal tract or by the chemoreceptor trigger zone (e1Z). The latter is probably the primary site for emetic activity of most cance...
متن کاملThe effect of antiemetics in childhood gastroenteritis
INTRODUCTION Diarrheal diseases are the second leading cause of childhood morbidity and mortality in developing countries and an important cause of malnutrition. An estimated 0.75 million children below 5 years of age die from diarrhea. Vomiting associated with acute gastroenteritis (AGE) is a distressing symptom and limits the success of oral rehydration in AGE leading to an increased use of i...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 1992
ISSN: 0923-7534
DOI: 10.1093/oxfordjournals.annonc.a058316